Project CBD’s Top Article On Depression by Stacey Kerr


Depressed? Could cannabis help? These two questions lead to many more, none of them easy to answer in today’s era of limited science on the topic. Some say cannabis helps pull them out of depression, and a few admit that they feel a bit more depressed if they use it. What is the real story of cannabis and depression?


• Many patients claim that medical marijuana is an effective anti-depressant.
• Those who use cannabis recreationally often use it for mood enhancement, effectively avoiding major depression and the need for pharmaceutical intervention.
• A dysregulated endocannabinoid system is implicated in clinical depression.
• Both THC and CBD have been shown to be beneficial in animal models of depression, but clinical research thus far has been lacking.
• In states with robust medical marijuana programs, the legalization of cannabis for therapeutic use is associated with a five percent decrease in total suicide rate and a greater decrease in the suicide rate of young men in their 20’s and 30’s.

Depressed? Could cannabis help?

Depressed? Could cannabis help?


Our moods are affected by our environment, life situations, genetics, and brain activity. Some individuals are simply happier than others, and research on CB1 (cannabinoid) receptor genes gives us some clues to why that happens. [1] However, even though some are seemingy genetically destined to find and maintain happiness easier, other variables in life cannot be minimized.

Endocannabinoid system (ECS) activity in the brain affects feelings of anxiety and depression. This connection was all too obvious when the medication rimonabant, a CB1 antagonist, was released as a treatment for obesity. Rimonabant was quickly withdrawn from the market because of undesirable psychiatric side effects such as anxiety, depression and thoughts of suicide.

This definitively showed that blocking the brain’s CB1 receptors had unexpected severe consequences, and also showed the need for more research on the relationship between the ECS and mood.


The DSM major depressive disorder (MDD) diagnostic criteria require the occurrence of one or more major depressive episodes.

Symptoms include the following:

  •     Depressed mood
  •     Diminished loss of interest or pleasure in almost all activities
  •     Significant weight or appetite disturbance
  •     Sleep disturbance
  •     Speeding or slowing of muscle movement
  •     Loss of energy or fatigue
  •     Feelings of worthlessness – low self-esteem
  •     Diminished ability to think, concentrate and make decisions
  •     Recurrent thoughts of death, dying or suicide
  •     Longstanding interpersonal rejection ideation (ie. others would be better off without me); specific suicide plan; suicide attempt

Additional DSM Major Depressive Disorder Criteria:

In MDD, either a depressed mood or anhedonia (inability to feel pleasure) must be present.

In addition to the criteria for a major depressive episode, the episode must:

  •     Be at least two weeks long
  •     Cause significant distress or severely impact social, occupational or other important life areas
  •     Not be precipitated by drug use
  •     Not meet the criteria for another mental disorder like schizophrenia or bipolar disorder
  •     Not be better explained by bereavement such as the loss experienced after a death

CAN CANNABIS CAUSE DEPRESSION? Find out in the following link…

Thank you to Project CBD; For Full Article and a Wealth of more information please click the following link


  • I would like to sound off here on the medicinal use of marijuana for help with MY mental illness. And I would like to add the disclaimer that I am bipolar, and this is my personal experience with marijuana. Also note that marijuana is like any psych med in that it may work for some and not for others.

    After my diagnosis, I spent five years heavily medicated. I was on 4 antidepressants plus an atypical antipsychotic. I am a magnet for side effects, and after five years (and a life-altering manic episode), it was clear the side effects were outweighing the benefits. My doctor and I decided to take me off of all of my meds so that we could establish a baseline of my symptoms, see what my illness really looked like. I was also smoking pot at this time, which I continued to do.

    Since I was taken off my medications, I have been shockingly stable. I find that marijuana lightens my heaviest moods. It lifts a little bit of the heavy weight of depression. Levity, it gives me a little levity when I feel otherwise hopeless. It helps me to eat and to sleep. It helps me to control my anxiety. When I am manic, it helps to slow down my racing thoughts. It soothes me. I have been able to go back to work, hold a job, show up to work everyday, and be a participant in my own life. I consider it a miracle medicine.

    It has been a total game changer for me, with zero scary side effects. I am grateful for cannabis everyday.

    Liked by 1 person

    • Thank you so much for sharing; personal experiences are of the utmost importance and so very much appreciated.
      I am glad you are doing so well and would love to share your full experience. Could we talk?
      All the best for the year ahead and I hope to speak with you.


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